Daclizumab reduces CD25 levels on T cells through monocyte-mediated trogocytosis
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چکیده
منابع مشابه
Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo
Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells. Objective: To investigate the cytotoxic and immunomodulatory properties of Arteether in-vivo and in-vitro. Methods: In this study, we ...
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Background: Sclareol is a phytochemical used in people's diet in Southeast Asia. Objective: To investigate the immunotherapeutic effectiveness of Sclareol against breast cancer by direct intraperitoneal injection. Methods: Sclareol was isolated and purified from Salvia sclarea. Effect of Sclareol on cell growth inhibition was evaluated by MTT assay. Intraperitoneally injected Sclareol effects o...
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Monoclonal antibodies are a promising new class of therapeutic agents that can be employed to target specific molecules of the immune system or any tissue. They are currently being tested in a number of clinical trials in autoimmune diseases such as multiple sclerosis (MS). One of these, the humanized monoclonal anti-CD25 antibody daclizumab (Zenapax), is directed against the interleukin-2 (IL-...
متن کاملsclareol reduces cd4+ cd25+ foxp3+ t-reg cells in a breast cancer model in vivo
background: sclareol is a phytochemical used in people's diet in southeast asia. objective: to investigate the immunotherapeutic effectiveness of sclareol against breast cancer by direct intraperitoneal injection. methods: sclareol was isolated and purified from salvia sclarea. effect of sclareol on cell growth inhibition was evaluated by mtt assay. intraperitoneally injected sclareol effe...
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background: chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. in vitro studies have been shown that arteether (are) induces apoptosis in tumor cells, but not in normal cells. objective: to investigate the cytotoxic and immunomodulatory properties of arteether in-vivo and in-vitro. methods: in this study, we ...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2013
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458513494488